HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 53656586, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (3-Bromopropyl)benzene | HCID 12503 | — |
| Reactant | 2-Bromomethylnaphthalene | HCID 70320 | — |
| Reactant | (3S,4S)-tert-Butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate | HCID 21713087 | — |
| Reactant | tert-butyl (3RS,4RS)-3-hydroxy-4-[4-(3-phenyl-propoxy)-phenyl]-piperidine-1-carboxylate | HCID 86604476 | — |
| Product | HCID 53656586 | HCID 53656586 | — |
Reaction Steps
In an analogous manner to that described in Example 44 (e), by alkylating tert-butyl (3RS,4RS)-3-hydroxy-4-(4-hydroxy-phenyl)-piperidine-1-carboxylate [Example 46 (b)] with 1-bromo-3-phenyl-propane in the presence of potassium carbonate, tert-butyl (3RS,4RS)-3-hydroxy-4-[4-(3-phenyl-propoxy)-phenyl]-piperidine-1-carboxylate, alkylation of which analogously to Example 1 (g) with 2-bromomethyl-naphthalene yielded tert-butyl (3RS,4RS)-3-(naphthalen-2-ylmethoxy)-4-[4-(3-phenyl-propoxy)-phenyl]-piperidine-1-carboxylate as a colourless solid; MS: 551 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06051712 |
| Source dataset | uspto-grants-2000_04 |
| ORD ID | ord-f0af4f94e7c54d61833f3e94efca5a64 |
| Source note | uspto-grants-2000_04 |