戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 1005169作成日：2026年10月25日

2-Chloromethyl-1,4-dimethoxy-naphthalene → tert-butyl (3RS,4RS)-3-(1,4-dimethoxy-naphthalen-2-ylmethoxy)-4-[4-(2-phenethyloxy-ethoxy)-phenyl]-piperidine-1-carboxylate

https://huagongshe.com/reaction/1005169

反応式

関与物質

役割名称HCID仕込み量
反応物2-Chloromethyl-1,4-dimethoxy-naphthaleneHCID 14854802—
反応物tert-butyl (3RS,4RS)-3-hydroxy-4-[4-(2-phenethyloxy-ethoxy)-phenyl]-piperidine-1-carboxylateHCID 86604483—
生成物tert-butyl (3RS,4RS)-3-(1,4-dimethoxy-naphthalen-2-ylmethoxy)-4-[4-(2-phenethyloxy-ethoxy)-phenyl]-piperidine-1-carboxylateHCID 86604484—

反応手順

In an analogous manner to that described in Example 1 (g), by alkylating tert-butyl (3RS,4RS)-3-hydroxy-4-[4-(2-phenethyloxy-ethoxy)-phenyl]-piperidine-1-carboxylate with 2-chloromethyl-1,4-dimethoxy-naphthalene there was obtained tert-butyl (3RS,4RS)-3-(1,4-dimethoxy-naphthalen-2-ylmethoxy)-4-[4-(2-phenethyloxy-ethoxy)-phenyl]-piperidine-1-carboxylate as a yellow solid; MS: 642 (M+H)+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06051712
出典データセットuspto-grants-2000_04
ORD IDord-2cc1352c5a9f4cfc8d11b5e5d501c2c4
出典メモuspto-grants-2000_04