HRID1005182

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22128465

未命名化合物

结构：CC(C)(C)OC(=O)N1CCC(c2ccc(OCCCOCc3ccsc3)cc2)C(O)C1

HCID54392112

未命名化合物

PRODUCTS

生成物

结构：COCCCOc1cc(COC2CN(C(=O)OC(C)(C)C)CCC2c2ccc(OCCCOCc3ccsc3)cc2)cc2c(OC)cccc12

HCID54264839

未命名化合物

PROCEDURE

实验过程

In an analogous manner to that described in Example 1 (g), by alkylating tert-butyl (3RS,4RS)-3-hydroxy-4-[4-[3-(thiophen-3-ylmethoxy)-propoxy]-phenyl]-piperidine-1-carboxylate with 3-chloromethyl-5-methoxy-1-(3-methoxy-propoxy)-naphthalene [Example 123 (t)] there was obtained tert-butyl (3RS,4RS)-3-[8-methoxy-4-(3-methoxy-propoxy)-naphthalen-2-ylmethoxy]-4{4-[3-(thiophen-3-ylmethoxy)-propoxy]-phenyl}-piperidine-1-carboxylate as a pale yellow, viscous oil; MS: 723 (M+NH4)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3a2455686f594ff48eb00fb29ede4f57
来源数据集: uspto-grants-2000_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06051712
来源说明: uspto-grants-2000_04

反应 SMILES

[OH:1][CH:2]1[CH:7]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][CH2:17][O:18][CH2:19][C:20]3[CH:24]=[CH:23][S:22][CH:21]=3)=[CH:10][CH:9]=2)[CH2:6][CH2:5][N:4]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:3]1.Cl[CH2:33][C:34]1[CH:35]=[C:36]([O:46][CH2:47][CH2:48][CH2:49][O:50][CH3:51])[C:37]2[C:42]([CH:43]=1)=[C:41]([O:44][CH3:45])[CH:40]=[CH:39][CH:38]=2>>[CH3:45][O:44][C:41]1[CH:40]=[CH:39][CH:38]=[C:37]2[C:42]=1[CH:43]=[C:34]([CH2:33][O:1][CH:2]1[CH:7]([C:8]3[CH:9]=[CH:10][C:11]([O:14][CH2:15][CH2:16][CH2:17][O:18][CH2:19][C:20]4[CH:24]=[CH:23][S:22][CH:21]=4)=[CH:12][CH:13]=3)[CH2:6][CH2:5][N:4]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:3]1)[CH:35]=[C:36]2[O:46][CH2:47][CH2:48][CH2:49][O:50][CH3:51]