HRID1005186

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22126964

未命名化合物

结构：CC(C)(C)OC(=O)N1CCC(c2ccc(OCCCSCc3ccccc3)cc2)C(O)C1

HCID53878207

未命名化合物

PRODUCTS

生成物

结构：COc1cc(COC2CN(C(=O)OC(C)(C)C)CCC2c2ccc(OCCCSCc3ccccc3)cc2)cc2c(OC)cccc12

HCID86604492

未命名化合物

PROCEDURE

实验过程

(ee) In an analogous manner to that described in Example 1 (g), by alkylating tert-butyl (3RS,4RS)-4-[4-(3-benzylsulphanyl-propoxy)-phenyl]-3-hydroxy-piperidine-1-carboxylate [Example 123 d)] with 3-chloromethyl-1,5-dimethoxy-naphthalene [Example 123 r)] there was obtained tert-butyl (3RS,4RS)-4-[4-(3-benzylsulphanyl-propoxy)-phenyl]-3-(4,8-dimethoxy-naphthalen-2-ylmethoxy)-piperidine-1-carboxylate as a yellow, viscous oil; MS: 658 (M+H)+.

WORKUP

后处理

customExample 123 d

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4046f038873e46088f34dd24a555c425
来源数据集: uspto-grants-2000_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06051712
来源说明: uspto-grants-2000_04

反应 SMILES

[CH2:1]([S:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([CH:19]2[CH2:24][CH2:23][N:22]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:21][CH:20]2[OH:32])=[CH:15][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:34][C:35]1[CH:36]=[C:37]([O:47][CH3:48])[C:38]2[C:43]([CH:44]=1)=[C:42]([O:45][CH3:46])[CH:41]=[CH:40][CH:39]=2>>[CH2:1]([S:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([CH:19]2[CH2:24][CH2:23][N:22]([C:25]([O:27][C:28]([CH3:29])([CH3:31])[CH3:30])=[O:26])[CH2:21][CH:20]2[O:32][CH2:34][C:35]2[CH:36]=[C:37]([O:47][CH3:48])[C:38]3[C:43](=[C:42]([O:45][CH3:46])[CH:41]=[CH:40][CH:39]=3)[CH:44]=2)=[CH:15][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1