Triethylamine → HCID 18791027, compound

Participants

Reaction Steps

1 g (10 mmol) of triethylamine and 0.8 g (6.6 mmol) of methanesulfonyl chloride were added in succession to a solution of 1.2 g (3.3 mmol) of 3-(5-amino-4-chloro-2-fluorophenyl)-1-methyl-4,5-di(trifluoromethyl)-1H-pyrazole in 30 ml of tetrahydrofuran. The reaction mixture was subsequently stirred for 16 hours, whereupon it was concentrated. The residue was treated with water and ethyl acetate. The organic phase which had been separated off was washed with water and saturated aqueous sodium chloride solution, dried over magnesium sulfate and finally concentrated. Yield: quantitative.

Provenance & Evidence