Nitric Acid → HCID 18791015, compound

HRID 1005285Notes

Reaction equation

HRID 1005285 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:13]([C:14]([F:17])([F:16])[F:15])=[C:12]([C:18]([F:21])([F:20])[F:19])[N:11]([CH3:22])[N:10]=1.[N+:23]([O-])([OH:25])=[O:24]>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([N+:23]([O-:25])=[O:24])=[CH:4][C:3]=1[C:9]1[C:13]([C:14]([F:16])([F:17])[F:15])=[C:12]([C:18]([F:21])([F:20])[F:19])[N:11]([CH3:22])[N:10]=1

Participants

3

Reactant 2

HCID 944Nitric AcidHCID 18791013HCID 18791013, compound

Product 1

HCID 18791015HCID 18791015, compound

Procedure

21 g (58 mmol) of 3-(2,4-dichlorophenyl)-1-methyl-4,5-di-(trifluoromethyl)-1H-pyrazole were added, at (-30)° C., to 250 ml of concentrated nitric acid, whereupon the mixture was stirred for 1 hour at (-10)° C. The solution was subsequently stirred into 1.2 l of ice-water. The product was then extracted with dichloromethane. The organic phase was dried over magnesium sulfate and concentrated.

Workup

  1. extractionThe product was then extracted with dichloromethane
  2. dry with materialThe organic phase was dried over magnesium sulfate
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-825da1bc03534f2f8784b7b98000254e
Source dataset
uspto-grants-2000_04
Patent number
US06054412

Reaction notes

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