Acetic Acid → 8-Methyl-1-oxothiochroman-4-one-7-carboxylic acid

Participants

Reaction Steps

7.0 g (31.5 mmol) of 8-methylthiochroman-4-one-7-carboxylic acid are initially introduced into 70 ml of acetic acid together with a spatula tipful of sodium tungstate. 3.6 g (31.5 mmol) of 30% strength hydrogen peroxide solution are added dropwise at 50° C. and the reaction solution is subsequently stirred for 3 hours. It is then stirred into water and the product is extracted with ethyl acetate. The organic phase is dried and the solvent is removed. The product is purified by chromatography.

Provenance & Evidence