Dichloromethane → HCID 15335241, compound

Participants

Reaction Conditions

Reaction Steps

14.3 g (0.06 mmol) of 3-carboxymethylthio-2-methylbenzoic acid are dissolved in 300 ml of methylene chloride and 13.1 g (0.11 mmol) of thionyl chloride are added dropwise. The mixture is refluxed for 1 hour and the solvent and excess thionyl chloride are then distilled off. The residue is taken up in 100 ml of methylene chloride and treated with 31.8 g (0.24 mmol) of aluminum trichloride. The reaction is stirred at about 20° C. for 1 hour. The mixture is then added to ice-water and the organic phase is separated off. After washing and drying the organic phase, the solvent is removed. The product is reacted further without purification.

Provenance & Evidence