2-(Phenoxazin-10-yl)ethyl methanesulfonate → Ethyl 3-[4-[2-(phenoxazin-10-yl)ethoxy]phenyl]-2-hydroxypropanoate

HRID 1005315Notes

Reaction equation

HRID 1005315 reaction equation
CS([O:5][CH2:6][CH2:7][N:8]1[C:21]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[O:15][C:14]2[C:9]1=[CH:10][CH:11]=[CH:12][CH:13]=2)(=O)=O.[OH:22][CH:23]([CH2:29][C:30]1[CH:35]=[CH:34][C:33](O)=[CH:32][CH:31]=1)[C:24]([O:26][CH2:27][CH3:28])=[O:25]>>[CH:20]1[C:21]2[N:8]([CH2:7][CH2:6][O:5][C:33]3[CH:32]=[CH:31][C:30]([CH2:29][CH:23]([OH:22])[C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:35][CH:34]=3)[C:9]3[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=3)[O:15][C:16]=2[CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 112204632-(Phenoxazin-10-yl)ethyl methanesulfonateHCID 21930973Ethyl p-hydroxyphenyllactate

Product 1

HCID 9823390Ethyl 3-[4-[2-(phenoxazin-10-yl)ethoxy]phenyl]-2-hydroxypropanoateYield 43%

Procedure

The title compound (1.06 g, 43%) was prepared as a pale yellow liquid from 2-(phenoxazin-10-yl)ethyl methanesulfonate (1.8 g, 5.9 mmol) and ethyl 2-hydroxy-3-(4-hydroxyphenyl)propanoate (1.36 g, 6.49 mmol) by an analogous procedure to that described in example 6 (Method B).

Sources & evidence

ORD record
ord-64fb9999c79f494aa1bb082728223fbc
Source dataset
uspto-grants-2000_04
Patent number
US06054453

Reaction notes

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