(+-)-3-Quinuclidinol → HCID 2738284, compound

HRID 1005326Notes

Reaction equation

HRID 1005326 reaction equation
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([OH:9])[CH2:2]2.[F:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[N:17]=[C:18]=[O:19]>>[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([O:9][C:18](=[O:19])[NH:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[F:10])[CH2:2]2

Participants

3

Reactant 2

HCID 15381(+-)-3-QuinuclidinolHCID 855882-Fluorophenyl isocyanate

Product 1

HCID 2738284HCID 2738284, compoundYield 79%

Procedure

3-Quinuclidinol and 2-fluorophenyl isocyanate were used. The reaction solution was evaporated under reduced pressure, and the residual solid was recrystallized from ethyl acetate to afford the title compound (79%) as a white solid: mp 124.0-126.0° C.; FAB LRMS m /z (relative intensity %) 265 (MH+, 22), 110 (100).

Workup

  1. customThe reaction solution was evaporated under reduced pressure
  2. customthe residual solid was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-22c493280b214d30b932f8ee9f3bec3e
Source dataset
uspto-grants-2000_04
Patent number
US06054464

Reaction notes

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