(+-)-3-Quinuclidinol → HCID 44722650, compound

HRID 1005327Notes

Reaction equation

HRID 1005327 reaction equation
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([OH:9])[CH2:2]2.[CH3:10][O:11][C:12]1[CH:13]=[C:14]([N:18]=[C:19]=[O:20])[CH:15]=[CH:16][CH:17]=1>>[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([O:9][C:19](=[O:20])[NH:18][C:14]1[CH:15]=[CH:16][CH:17]=[C:12]([O:11][CH3:10])[CH:13]=1)[CH2:2]2

Participants

3

Reactant 2

HCID 15381(+-)-3-QuinuclidinolHCID 878433-Methoxyphenyl isocyanate

Product 1

HCID 44722650HCID 44722650, compoundYield 60%

Procedure

3-Quinuclidinol and 3-methoxyphenyl isocyanate were used. The reaction solution was evaporated under reduced pressure, and the residual solid was recrystallized from ethyl acetate to afford the title compound (60%) as a white solid: mp 130.5-132.0° C.; FAB LRMS m /z (relative intensity, %) 278 (18), 277 (MH+, 100).

Workup

  1. customThe reaction solution was evaporated under reduced pressure
  2. customthe residual solid was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-20b3264149244685b570b90f5db423b7
Source dataset
uspto-grants-2000_04
Patent number
US06054464

Reaction notes

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