反应详情

To a solution of t butyl 2-(4-methylphenyl)-2,2-dimethylacetate (19.4 g, 83 mmol) in carbon tetrachloride (350 mL) was added N-bromosuccinimide (16.2 g, 92 mmol) and benzoyl peroxide (0.5 g). The mixture was heated under reflux for 1 hour. The mixture was cooled to rt, and the precipitate was removed by filtration. The filtrate was washed with 10% NaHCO3 and brine, dried (Na2SO4), and evaporated to give t butyl 2-(4-bromomethylphenyl)-2,2-dimethylacetate as a light yellow oil (26.4 g, 100%).

1. temperatureThe mixture was heated
2. temperatureunder reflux for 1 hour
3. customthe precipitate was removed by filtration
4. washThe filtrate was washed with 10% NaHCO3 and brine
5. dry with materialdried (Na2SO4)
6. customevaporated