関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Iodine | HCID 807 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | 2-Hydroxy-4-methyl-3-nitropyridine | HCID 345370 | — |
| 反応物 | Sodium Iodate | HCID 23675764 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Sulfuric Acid | HCID 1118 | — |
| 生成物 | 5-Iodo-4-methyl-3-nitro-1,2-dihydropyridin-2-one | HCID 21706514 | — |
反応手順
To a solution of 4-methyl-3-nitro-2-pyridone (2.00 g, 13 mmol) in acetic acid (12 mL) and concentrated sulfuric acid (1.6 mL) was added iodine (1.32 g) and sodium iodate (0.55 g). The mixture was heated at 75° C. for 2.5 hours and then stirred at rt overnight. Water (100 mL) was added, and the precipitated 5-iodo-4-methyl-3-nitro-2-pyridone was collected by filtration (2.97 g, 82%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06054470 |
|---|
| 出典データセット | uspto-grants-2000_04 |
|---|
| ORD ID | ord-4e5a26406f1f46738924a78380e55939 |
|---|
| 出典メモ | uspto-grants-2000_04 |
|---|
