HCID 15463557, compound → HCID 15463561, compound

Participants

Reaction Steps

To a glass bomb was added 100 mg (0.296 mmol) of the compound of Example 2, the 3-cyanophenyl derivative, and 10 mg of freshly washed Raney nickel in 6 mL of a 5:1 MeOH:NH4OH(conc.) solution. The reaction vessel was charged with 50 psi hydrogen and shaken overnight. Upon completion the reaction was filtered through Celite and the solvent was evaporated in vacuo. Chromatography of the crude solid (Silica gel/Hexanes:Acetone 2:1) produced 65 mg (64%) of the desired amine as an off-white solid. LRMS m/z (ESI) 342.3 (M+H).

Provenance & Evidence