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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1005493Generated: November 2, 2026

Ethyl Acrylate → Ethyl 3-(2-ethoxycarbonylethyl)amino-2,2-dimethylbutanoate

https://huagongshe.com/reaction/1005493

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl AcrylateHCID 8821—
ReactantEthyl 3-amino-2,2-dimethylbutanoateHCID 23283845—
ProductEthyl 3-(2-ethoxycarbonylethyl)amino-2,2-dimethylbutanoateHCID 23283843—

Reaction Steps

In the second stage of the reaction, the ethyl 3-amino-2,2-dimethylbutanoate derivative 4 is reacted with ethyl acrylate to obtain the corresponding ethyl 3-(2-ethoxycarbonylethyl)amino-2,2-dimethylbutanoate derivative 5--which in the case of the preparation of BIII 277 might be, for example: ethyl 3-(2-ethoxycarbonylethyl)amino-4-(3-methoxyphenyl)-2,2-dimethylbutanoate (R2 =CH3O): ##STR4##

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06054604
Source datasetuspto-grants-2000_04
ORD IDord-90bf18aa2d3d4c0bae137f7717060207
Source noteuspto-grants-2000_04