HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[5-(3,5-Dimethyl-phenylsulfanyl)-4-isopropyl-2-methyl-imidazol-1-ylmethoxy]-ethanol → 5-(3,5-Dimethylphenylthio)-4-isopropyl-1-[2-(1-methoxycycloheptyloxy)ethoxymethyl]-2-methyl-1H-imidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[5-(3,5-Dimethyl-phenylsulfanyl)-4-isopropyl-2-methyl-imidazol-1-ylmethoxy]-ethanol | HCID 478180 | — |
| Reactant | 1,1-Dimethoxycycloheptane | HCID 12892877 | — |
| Product | 5-(3,5-Dimethylphenylthio)-4-isopropyl-1-[2-(1-methoxycycloheptyloxy)ethoxymethyl]-2-methyl-1H-imidazole | HCID 18792029 | 69.5% |
Reaction Steps
The compound 1 (301 mg, 0.9 mmol) was converted to the acetal with 1,1-dimethoxycycloheptane (1.30 g, 9 mmol) in the same manner as the example 1 to give the compound 4 (288 mg, 67%). Rf 0.68 (Al2O3 60-type E, 2:1 hexane -EtOAc).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06054591 |
| Source dataset | uspto-grants-2000_04 |
| ORD ID | ord-9cf9a3a69ead41bb833b5f90a0494f37 |
| Source note | uspto-grants-2000_04 |