2-(5-(3,5-Dichlorophenylthio)-4-isopropyl-1-methyl-1H-imidazol-2-yl)ethanol → HCID 18792028, compound

HRID 1005522Notes

Reaction equation

HRID 1005522 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9][C:10]2[N:14]([CH3:15])[C:13]([CH2:16][CH2:17][OH:18])=[N:12][C:11]=2[CH:19]([CH3:21])[CH3:20])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[CH2:22]([O:24][C:25]1(OCC)[CH:32]2[CH2:33][CH:28]3[CH2:29][CH:30]([CH2:34][CH:26]1[CH2:27]3)[CH2:31]2)[CH3:23]>>[Cl:8][C:6]1[CH:5]=[C:4]([S:9][C:10]2[N:14]([CH3:15])[C:13]([CH2:16][CH2:17][O:18][C:25]3([O:24][CH2:22][CH3:23])[CH:32]4[CH2:33][CH:28]5[CH2:29][CH:30]([CH2:34][CH:26]3[CH2:27]5)[CH2:31]4)=[N:12][C:11]=2[CH:19]([CH3:21])[CH3:20])[CH:3]=[C:2]([Cl:1])[CH:7]=1

Participants

3

Reactant 2

HCID 4740102-(5-(3,5-Dichlorophenylthio)-4-isopropyl-1-methyl-1H-imidazol-2-yl)ethanolHCID 15544204HCID 15544204, compound

Product 1

HCID 18792028HCID 18792028, compoundYield 47.6%

Procedure

The compound 22 (345 mg, 1 mmol) was converted to the acetal with 2,2-diethoxyadamantane (2.28 g, 10 mmol) in the same manner as the example 20 to give the compound 24 (249 mg, 47.5%) as oil.

Sources & evidence

ORD record
ord-d38c16debef94630881d48cbccaf339f
Source dataset
uspto-grants-2000_04
Patent number
US06054591

Reaction notes

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