2-(5-(3,5-Dichlorophenylthio)-4-isopropyl-1-methyl-1H-imidazol-2-yl)ethanol → 5-(3,5-Dichlorophenylthio)-4-isopropyl-2-[2-(1-methoxycycloheptyloxy)ethyl]-1-methyl-1H-imidazole

HRID 1005523Notes

Reaction equation

HRID 1005523 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9][C:10]2[N:14]([CH3:15])[C:13]([CH2:16][CH2:17][OH:18])=[N:12][C:11]=2[CH:19]([CH3:21])[CH3:20])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[CH3:22][O:23][C:24]1(OC)[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>>[Cl:8][C:6]1[CH:5]=[C:4]([S:9][C:10]2[N:14]([CH3:15])[C:13]([CH2:16][CH2:17][O:18][C:24]3([O:23][CH3:22])[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]3)=[N:12][C:11]=2[CH:19]([CH3:21])[CH3:20])[CH:3]=[C:2]([Cl:1])[CH:7]=1

Participants

3

Reactant 2

HCID 4740102-(5-(3,5-Dichlorophenylthio)-4-isopropyl-1-methyl-1H-imidazol-2-yl)ethanolHCID 128928771,1-Dimethoxycycloheptane

Product 1

HCID 187920135-(3,5-Dichlorophenylthio)-4-isopropyl-2-[2-(1-methoxycycloheptyloxy)ethyl]-1-methyl-1H-imidazoleYield 33.5%

Procedure

The compound 22 (345 mg, 1 mmol) was converted to the acetal with 1,1-dimethoxycycloheptane (1.58 g, 10 mmol) in the same manner as the example 20 to give the compound 25 (158 mg, 33.5%) as oil.

Sources & evidence

ORD record
ord-d1c45cfad295412b8c8b65e856e62ec8
Source dataset
uspto-grants-2000_04
Patent number
US06054591

Reaction notes

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