2-(5-(3,5-Dichlorophenylthio)-4-isopropyl-1-methyl-1H-imidazol-2-yl)ethanol → 5-(3,5-Dichlorophenylthio)-4-isopropyl-2-[2-(1-n-butoxycycloheptyloxy)ethyl]-1-methyl-1H-imidazole

Participants

Reaction Steps

The compound 22 (345 mg, 1 mmol) was converted to the acetal with 1,1-di-n-butoxycycloheptane (2.42 g, 10 mmol) in the same manner as the example 20 to give the compound 29 (107 mg, 20.8%). PMR (CDCl3 -0.1% d5 -Py): δH 0.90 (3 H, t, J 7.4 Hz, CH3) 1.24 (6H, d, J 7Hz, (CH3)2C), 3.00 (2H, t, J 6Hz, CH2 -Im), 3.11 (3 H, m, OCH2CH3, (CH3)2CH), 3.52(3 H, s, NCH3), 3.71 (2 H, t, J 6 Hz, OCH2), 6.83 (2 H, d, J 1.6 Hz, arom-H), 7.12 (t-like, arom-H). Elementary analysis (for C26H38N2O2Cl2S) Calcd. : C, 60.80% H, 7.46% N, 5.46% Found: C, 60.99% H, 6.56% N, 5.41%

Provenance & Evidence