2-(5-(3,5-Dichlorophenylthio)-4-isopropyl-1-methyl-1H-imidazol-2-yl)ethanol → HCID 18791980, compound

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Reaction Steps

The compound 22 (345 mg, 1 mmol) was converted to the acetal with 1-ethoxycyclooctene (1.61 g, 10 mmol) in the same manner as the example 20 to give the compound 31 (232 mg, 46%). Rf 0.54 (Al2O3 hexane-EtOAc 4:1) PMR (CDCl3 -0.1% d5 -Py): δH1.06 (3 H, d, J 7 Hz), 1.37-1.80 (14 H, m), 3.00 (2 H, t, J 6 Hz, CH2 -Im), 3.00 (2 H, t, J 6 Hz, CH2 -Im), 3.07 (2 H, q, J 7 Hz, OCH2), 3.10 (1 H, s, J 7 Hz, (CH3)2CH), 3.51 (3 H, s, NCH.3), 3.68 (2 H, t, J 6.2 Hz, OCH2), 6.82 (2 H, d, J 1.8 Hz, arom-H), 7.11 (1 H, t-like, arom-H) Elementary analysis (for C25H36N2O2Cl2S) Calcd. : C, 60.11% H, 7.26% N, 5.61% S, 6.42% Cl, 14.19% Found: C, 59.91% H, 7.36% N, 5.74% S, 6.23% Cl, 13.88%

Provenance & Evidence