2-(5-(3,5-Dichlorophenylthio)-4-isopropyl-1-methyl-1H-imidazol-2-yl)ethanol → HCID 18792054, compound

HRID 1005533Notes

Reaction equation

HRID 1005533 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9][C:10]2[N:14]([CH3:15])[C:13]([CH2:16][CH2:17][OH:18])=[N:12][C:11]=2[CH:19]([CH3:21])[CH3:20])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[CH2:22]([O:26][C:27]1(OCCCC)[CH2:31][CH2:30][CH2:29][CH2:28]1)[CH2:23][CH2:24][CH3:25]>>[Cl:8][C:6]1[CH:5]=[C:4]([S:9][C:10]2[N:14]([CH3:15])[C:13]([CH2:16][CH2:17][O:18][C:27]3([O:26][CH2:22][CH2:23][CH2:24][CH3:25])[CH2:31][CH2:30][CH2:29][CH2:28]3)=[N:12][C:11]=2[CH:19]([CH3:21])[CH3:20])[CH:3]=[C:2]([Cl:1])[CH:7]=1

Participants

3

Reactant 2

HCID 4740102-(5-(3,5-Dichlorophenylthio)-4-isopropyl-1-methyl-1H-imidazol-2-yl)ethanolHCID 18792031HCID 18792031, compound

Product 1

HCID 18792054HCID 18792054, compoundYield 29.3%

Procedure

The compound 22 (345 mg, 1 mmol) was converted to the acetal with 1,1-di-n-butoxycyclopentane (2.14 g, 10 mmol) in the same manner as the example 20 to give the compound 35 (142 mg, 29.3%).

Sources & evidence

ORD record
ord-53bf7b3d11a54906ac2be74a4b7d7ab0
Source dataset
uspto-grants-2000_04
Patent number
US06054591

Reaction notes

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