2-(5-(3,5-Dichlorophenylthio)-4-isopropyl-1-methyl-1H-imidazol-2-yl)ethanol → 5-(3,5-Dichlorophenylthio)-4-isopropyl-2-[2-(9-methoxy-9H-fluoren-9-yloxy)ethyl]-1-methyl-1H-imidazole

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Reaction Steps

The compound 22 (345 mg, 1 mmol) was converted to the acetal with 9,9-dimethoxyfluorene (2.26 g, 10 mmol) in the same manner as the example 20 to give the compound 43 (114 mg, 21.2%). Mp 130-131° C. PMR (CDCl3 -0.1% d5 -Py): δH1.24 (6 H, d, J 7 Hz, (CH3)2C), 3.20 (3 H, s, CH3O), 3.02 (2 H, m, CH2 -Im), 3.11 (1 H, m, (CH3)2CH), 3.42 (3 H, s, NCH3), 3.85 (2 H, t, J 6.2 Hz, OCH2), 6.8-7.6 (8 H, m, arom-H) Elementary analysis (for C29H28N2O2Cl2S) Calcd.: C, 64.56% H, 5.23% N, 5.19% S, 5.94% Cl, 13.14% Found: C, 64.65% H, 5.25% N, 5.10% S, 5.95% Cl, 12.89%

Provenance & Evidence