反应详情

The compound 22 (345 mg, 1 mmol) was converted to the enol ether with 4-tert-butyl-1,1-dimethoxycyclohexane (1 g, 5 mmol) in the same manner as the example 41 to give the compound 50 (337 mg, 70%). Mp 99.5-100.5° C. PMR (CDCl3 -0.1% d5 -Py): δH0.86 (9 H, s, t-Bu), 1.24 (6 H, d, J 4.4 Hz, (CH3)2C), 3.12 (2 H, t, J 4.2 Hz, CH2 -Im), 3.12 (1 H, m, (CH3)2CH), 3.50 (3 H, s, NCH3), 3.97 (2 H, m, OCH2), 4.61 (1 H, m, =CH), 6.77 (2 H, d, J 1 Hz, arom-H), 7.09 (1 H, t-like, arom-H). Elementary analysis (for C25H34N2Ocl2S) Calcd. : C, 62.35% H, 7.12% N, 5.82% S, 6.66% Cl, 14.72% Found: C, 62.56% H, 7.13% N, 5.76% S, 6.57% Cl, 14.43%