HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodomethyl pivalate → 2-[5-(3,5-Dichlorophenylthio)-4-isopropyl-2-methyl-imidazol-1-ylmethoxy]ethyl-2,2-dimethylpropionyloxymethyl ether
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodomethyl pivalate | HCID 104401 | — |
| Reactant | 2-[5-(3,5-Dichloro-phenylsulfanyl)-4-isopropyl-2-methyl-imidazol-1-ylmethoxy]-ethanol | HCID 478181 | — |
| Product | 2-[5-(3,5-Dichlorophenylthio)-4-isopropyl-2-methyl-imidazol-1-ylmethoxy]ethyl-2,2-dimethylpropionyloxymethyl ether | HCID 478187 | 32.3% |
Reaction Steps
The compound 8 (375 mg, 1 mmol) was alkylated with the pivaloyloxymethyl iodide (1.21 g, 5 mmol) under potassium carbonate (415 mg, 3 mmol) in the same manner as the example 61 to give the compound 77 (158 mg, 32%) as oil. Rf 0.26 (1:1 EtOAc - hexane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06054591 |
| Source dataset | uspto-grants-2000_04 |
| ORD ID | ord-6a7c0406897748ad92cebe9d6a1de0c0 |
| Source note | uspto-grants-2000_04 |