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HRID1005552

反应详情

EQUATION

反应方程式

HRID 1005552 的结构方程式

REACTANTS

反应物

3
结构：NC(=O)[O-]
HCID276

Carbamic acid, ion(1-)

CH2NO2-

结构：CC(C)c1nc(CO)n(Cc2ccncc2)c1Sc1cc(Cl)cc(Cl)c1
HCID9844329

{5-[(3,5-Dichlorophenyl)sulfanyl]-4-(propan-2-yl)-1-[(pyridin-4-yl)methyl]-1H-imidazol-2-yl}methanol

C19H19Cl2N3OS

结构：CC(=O)N=C=O
HCID12300404

Acetyl isocyanate

C3H3NO2

PRODUCTS

生成物

1
结构：CC(=O)NC(=O)OCc1nc(C(C)C)c(Sc2cc(Cl)cc(Cl)c2)n1Cc1ccncc1
HCID478192

未命名化合物

收率 76%

PROCEDURE

实验过程

5-(3,5-Dichlorophenylthio)-4-isoproyl-1-(4-pyridylmethyl)-2-hydroxymethyl-1H-imidazole (89) (245 mg, 0.6 mmol) prepared in accordance with the method as described in WO 96/10019 was converted to the carbamate with acetyl isocyanate (5 eq.) in the same manner as the example 66 to give the compound 90 (225 mg, 76%) as crystals. Mp. 135-137° C. Rf 0.32 (10:1 EtOAc - CH3OH).