HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbamate → [5-(3,5-dichlorophenyl)sulfanyl-4-isopropyl-1-(4-pyridylmethyl)imidazol-2-yl]methyl N-octanoylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbamate | HCID 276 | — |
| Reactant | {5-[(3,5-Dichlorophenyl)sulfanyl]-4-isopropyl-1-((pyridin-4-YL)methyl)imidazol-2-YL}methanol | HCID 9844329 | — |
| Reactant | Octanoyl isocyanate | HCID 18791988 | — |
| Product | [5-(3,5-dichlorophenyl)sulfanyl-4-isopropyl-1-(4-pyridylmethyl)imidazol-2-yl]methyl N-octanoylcarbamate | HCID 478193 | 56% |
Reaction Steps
The compound 89 (101-1048 (816 mg, 2.00 mmol) was converted to the carbamate with octanoyl isocyanate (5 eq.) in the same manner as the example 66 to give the compound 91 (650 mg, 56%) as crystals. Mp. 139-141° C. Rf 0.34 (EtOAc).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06054591 |
| Source dataset | uspto-grants-2000_04 |
| ORD ID | ord-e73b23b2ac694e30b105f27a1b58e5b1 |
| Source note | uspto-grants-2000_04 |