反应详情

A solution of 3-methoxy-4-nitro-N-[2-(5-ethoxycarbonylpent-1-yloxy)-4-methylphenyl]-N-methylbenzamide (7.6 g) in ethanol (76 ml) was treated with 1 N sodium hydroxide solution (33 ml) at ambient temperature and the mixture was stirred at the same temperature for 6 hours. The reaction was quenched by the dropwise addition of 1 N hydrochloric acid (35 ml). The mixture was concentrated and the residue was dissolved in a mixture of ethyl acetate and 1 N hydrochloric acid. The extracted organic layer was washed with brine and dried over magnesium sulfate. The suspension was filtered and the solvent was removed by evaporation to give 3-methoxy-4-nitro-N-[2-(5-carboxypent-1-yloxy)-4-methylphenyl]-N-methylbenzamide (7.1 g) as an oil.

1. customThe reaction was quenched by the dropwise addition of 1 N hydrochloric acid (35 ml)
2. concentrationThe mixture was concentrated
3. dissolutionthe residue was dissolved in a mixture of ethyl acetate and 1 N hydrochloric acid
4. washThe extracted organic layer was washed with brine
5. dry with materialdried over magnesium sulfate
6. filtrationThe suspension was filtered
7. customthe solvent was removed by evaporation