Methylamine → HCID 53946703, compound

Participants

Reaction Steps

A solution of (S)-4-[2-[1-methyl-3-(phthalimido)prop-1-yl]oxybenzoyl]amino-3-methoxy-N-methyl-N-[4-methyl-2-[5-(4-methylpiperazin-1-yl)carbonylpent-1-yloxy]phenyl]benzamide (1.1 g) in methanol (30 ml) was stirred and treated with 40% methylamine in methanol (10 ml). The reaction mixture was refluxed for 30 minutes. Then the solvent was concentrated and purified by silica gel column chromatography (SiO2 40 g, chloroform/methanol/ammonia=90/10/0.5) to give (S)-4-[2-[(3-amino-1-methylprop-1-yl)oxy]benzoyl]amino-3-methoxy-N-methyl-N-[4-methyl-2-[5-(4-methylpiperazin-1-yl)carbonylpent-1-yloxy]phenyl]benzamide.

Provenance & Evidence