Sodium borohydride → HCID 18791562, compound

Participants

Reaction Steps

To a solution of 4-[2-[(3-tert-butoxycarbonylaminoprop-1-yl)oxy]benzoyl]amino-3-methoxy-N-methyl-N-[2-[5-(4-oxopiperidin-1-yl)carbonylpent-1-yl]oxy-4-methylphenyl]benzamide (192 mg) in methanol (5 ml) was added sodium borohydride (19 mg) at ambient temperature and the mixture was stirred at the same temperate for 1 hour. The reaction was quenched with 0.5N hydrochloric acid (10 ml) and the mixture was extracted with chloroform (15 ml×3). The organic layer was washed with aqueous sodium hydrogen carbonate and brine, and the solution was dried over magnesium sulfate. The solvent was evaporated in vacuo to give 4-[2-[(3-tert-butoxycarbonylaminoprop-1-yl)oxy]benzoyl]amino-3-methoxy-N-methyl-N-[2-[5-(4-hydroxypiperidin-1-yl)carbonylpent-1-yl]oxy-4-methylphenyl]benzamide (199 mg).

Provenance & Evidence