HCID 18791358, compound → HCID 18791397, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-[2-(3-tert-butoxycarbonylaminoprop-1-yl)oxybenzoyl]amino-3-methoxy-N-methyl-N-[2-(5-ethoxycarbonylpent-1-yl)oxy-4-methylphenyl]benzamide (400 mg) in tetrahydrofuran (5 ml) was added lithium aluminum hydride (12 mg) at -23° C. and the mixture was stirred at 0° C. for 3 hours. The reaction was quenched with slow addition of 0.5N hydrochloric acid (15 ml) and the solution was stirred at ambient temperature for 20 minutes. The solution was extracted with chloroform (15 ml×3) and the organic layer was washed with aqueous saturated sodium bicarbonate solution and brine. The solution was dried over magnesium sulfate and the solvent was removed under reduced pressure to give 4-[2-(3-tert-butoxycarbonylaminoprop-1-yl)oxybenzoyl]amino-3-methoxy-N-methyl-N-[2-(6-hydroxyhex-1-yl)oxy-4-methylphenyl]benzamide (456 mg).

Provenance & Evidence