Trimethylsilyldiazomethane → HCID 18791582, compound

Participants

Reaction Steps

To a solution of 4-[2-[(3-tert-butoxycarbonylaminoprop-1-yl)oxy]benzoyl]amino-3-carboxymethoxy-N-methyl-N-[2-[5-(4-methylpiperazin-1-yl)carbonylpent-1-yloxy]-4-methylphenyl]benzamide (128 mg) in methanol (5 ml) was added dropwise trimethylsilyldiazomethane (5 ml, 2.0M n-hexane solution) and stirred at ambient temperature for 30 minutes. The solution was concentrated in vacuo and the residue was purified by preparative thin layer silica gel chromatography (chloroform:methanol:28% aqueous ammonia solution, 50:5:1) to give 4-[2-[(3-tert-butoxycarbonylaminoprop-1-yl)oxy]benzoyl]amino-3-methoxycarbonylmethoxy-N-methyl-N-[2-[5-(4-methylpiperazin-1-yl)carbonylpent-1-yloxy]-4-methylphenyl]benzamide (85 mg).

Provenance & Evidence