Sulfuric Acid → HCID 18791632, compound

Participants

Reaction Steps

To a solution of 4-[2-[(3-aminoprop-1-yl)oxy]benzoyl]amino-3-methoxy-N-methyl-N-[4-methyl-2-[5-(4-methylpiperazin-1-yl)carbonylpent-1-yloxy]phenyl]benzamide (7.35 g) in ethanol (230 ml) was added 0.5M sulfuric acid in ethanol (22.3 ml) at 80° C. The mixture was stirred for 24 hours at ambient temperature. The precipitate was filtered through a glass funnel followed by rinsing with ethanol. The resulting white, crystalline solid was dried over air for 7 days to give 4-[2-[(3-aminoprop-1-yl)oxy]benzoyl]amino-3-methoxy-N-methyl-N-[4- methyl-2-[5-(4-methylpiperazin-1-yl)carbonylpent-1-yloxy]phenyl]benzamide sulfate (5.2 g).

Provenance & Evidence