Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylcarbodiimide | HCID 12734 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Phytosphingosine | HCID 122121 | — |
| Reactant | 27-Stearoyloxyheptacosanoic acid | HCID 18469464 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Ceramide 1 | HCID 58418606 | — |
Reaction Steps
A mixture of 27-stearoyloxyheptacosanoic acid (8.88 g, 12.8 mmoles), tetrahydrofuran (120 ml), dried 1-hydroxybenzotriazole (4 g, 34.1 mmoles), phytosphingosine (3.91 g, 12.33 mmoles) and N,N'-diisopropylcarbodiimide (2.55 ml, 16.3 mmoles) was stirred under nitrogen for 2 hours at 40° C. and for another 4 hours at 50° C. After filtration and recrystallisation from hot chloroform 8.84 g of the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06054599 |
|---|
| Source dataset | uspto-grants-2000_04 |
|---|
| ORD ID | ord-ddf6e1687f9644ee8e86dbcb3b84eaa0 |
|---|
| Source note | uspto-grants-2000_04 |
|---|
