Water → (+/-)-2-Chloroacetyl-2-azabicyclo[2.2.1]-hept-5-en-3-one

10.1 g of (±)-2-azabicyclo[2.2.1]hept-5-en-3-one were dissolved in a mixture of dichloromethane (10 ml), pyridine (8.4 ml) and 0.22 g of 4-N,N-dimethylaminopyridine at 10° C. under nitrogen. 13.5 g of chloroacetyl chloride were added dropwise over the course of 1 h. The temperature rose to 44° C. The mixture was stirred for a further 2 h at room temperature. 100 ml of water were added to the solution. After phase separation, the aqueous phase was extracted with 100 ml of dichloromethane. The combined organic phases were dried with sodium sulphate and completely evaporated. The residue was boiled in 100 ml of diisopropyl ether under reflux in the presence of 1 g of active charcoal for 10 minutes. After hot filtration, the filtrate was cooled to room temperature, and the solid was filtered and dried. 10.35 g of title compound were obtained. The yield was 60%.

1. customrose to 44° C
2. customAfter phase separation
3. extractionthe aqueous phase was extracted with 100 ml of dichloromethane
4. dry with materialThe combined organic phases were dried with sodium sulphate
5. customcompletely evaporated
6. temperatureunder reflux in the presence of 1 g of active charcoal for 10 minutes
7. filtrationAfter hot filtration
8. temperaturethe filtrate was cooled to room temperature
9. filtrationthe solid was filtered
10. customdried

ORD record

ord-eeb7f07100c44423882d98171e09735b

Source dataset

uspto-grants-2004_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06787347B2