反应详情

In ethanol (20 ml) was dissolved 0.629 g of 6-ethoxycarbonylamino-1-methylisoquinoline (Preparation Example 32), and 8 N sodium hydroxide aqueous solution (6.8 ml), followed by heating under reflux for 1.5 hours. After cooling as it was to room temperature, an aqueous saturated ammonium chloride was added thereto, followed by extracting with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate and the solvent was evaporated, to give the title compound (0.311 g, 72%) as pale yellow crystals.

1. temperatureby heating
2. temperatureunder reflux for 1.5 hours
3. temperatureAfter cooling as it
4. customwas to room temperature
5. extractionby extracting with ethyl acetate
6. washThe extract was washed with brine
7. dry with materialdried over anhydrous magnesium sulfate
8. customthe solvent was evaporated