HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 22674179, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | HCID 22674077 | HCID 22674077 | — |
| Reactant | 8-Bromoquinolin-3-amine | HCID 22674161 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 22674179 | HCID 22674179 | 63.2% |
Reaction Steps
Pyridine (0.5 ml) and a solution of 6-ethyl-3-pyridinesulfonyl chloride (30 mg) in methylene chloride (0.5 ml) were added to 3-amino-8-bromoquinoline (18 mg, Preparation Example 5) at 0° C. After stirring at room temperature for 30 minutes, water was added thereto and the mixture was extracted with ethyl acetate. The extract was purified by preparative TLC (hexane-ethyl acetate=1:1), to give the title compound (20 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06787534B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-6e8b467d2c6048c0ab153c5adc694b8a |
| Source note | uspto-grants-2004_09 |