HCID 22674421, compound → HCID 22674397, compound

HRID 1005716Notes

Reaction equation

HRID 1005716 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([C:8]1[C:9]2[S:21][CH:20]=[CH:19][C:10]=2[N:11]=[C:12]([C:14]([O:16][CH2:17]C)=[O:15])[N:13]=1)=[O:7]>CO.O>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([C:8]1[C:9]2[S:21][CH:20]=[CH:19][C:10]=2[N:11]=[C:12]([C:14]([O:16][CH3:17])=[O:15])[N:13]=1)=[O:7]

Participants

4

Reactant 1

HCID 22674421HCID 22674421, compound

Product 1

HCID 22674397HCID 22674397, compoundYield 77.4%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of ethyl 4-(2-thienylcarbonyl)thieno[3,2-d]pyrimidine-2-carboxylate (100 mg, 0.31 mmol) in MeOH (5 mL) was refluxed for 2 h, cooled, diluted with water and filtered to give the title compound (73 mg, 74%) as a cream solid.

Workup

  1. temperaturecooled
  2. filtrationfiltered

Sources & evidence

ORD record
ord-d41a31027ea54e04bdadb435956f4c09
Source dataset
uspto-grants-2004_09
Patent number
US06787541B1

Reaction notes

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