Triethylamine → HCID 22674414, compound

Participants

Reaction Steps

A mixture of 4-(2-thienylcarbonyl)thieno[3,2-d]pyrimidine-2-carboxylic acid ( 290 mg, 1.0 mmol) and SOCl2 (4 mL) was refluxed for 30 min, concentrated in vacuo, and treated with CH2Cl2 (10 mL), Et3N (208 μL, 1.5 mmol) and N,N-dimethylethylenediamine (120 μL, 1.1 mmol). The reaction mixture was stirred at room temperature for 1 h, poured into sat. NaHCO3, extracted with EtOAc (2×10 mL), dried (MgSO4), concentrated in vacuo then triturated with EtOAc and filtered to give the title compound (234 mg, 65%) as a cream solid.

Provenance & Evidence