Potassium Nitrate → HCID 178513826, compound

HRID 1005744Notes

Reaction equation

HRID 1005744 reaction equation
[OH:1][C:2]1[C:3]([C:8]([NH2:10])=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1.[N+:11]([O-])([O-:13])=[O:12].[K+]>S(=O)(=O)(O)O.O>[OH:1][C:2]1[C:3]([C:8]([NH2:10])=[O:9])=[N:4][C:5]([N+:11]([O-:13])=[O:12])=[CH:6][N:7]=1

Participants

5

Reactant 2

HCID 24434Potassium NitrateHCID 178513804HCID 178513804, compound

Product 1

HCID 178513826HCID 178513826, compoundYield 46.3%

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 1118Sulfuric AcidSolvent

Conditions

Temperature
40 °C

Procedure

In 24 mL of concentrated sulfuric acid is suspended 4.00 g of 3-hydroxy-2-pyrazinecarboxamide. To the suspension is added 3.09 g of potassium nitrate under ice-cooling. The resulting mixture is stirred at 40° C. for 3 hours. The reaction mixture is poured into 240 mL of water, and the deposited crystals are collected by filtration. The crystals thus obtained are suspended in 80 mL of water and heated under reflux for 30 minutes. After cooling, the crystals are collected by filtration to obtain 2.45 g of 3-hydroxy-6-nitro-2-pyrazinecarboxamide.

Workup

  1. temperaturecooling
  2. filtrationthe deposited crystals are collected by filtration
  3. customThe crystals thus obtained
  4. temperatureheated
  5. temperatureunder reflux for 30 minutes
  6. temperatureAfter cooling
  7. filtrationthe crystals are collected by filtration

Sources & evidence

ORD record
ord-13b2721618f040d8b067a01ad03b05b1
Source dataset
uspto-grants-2004_09
Patent number
US06787544B2

Reaction notes

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