D-Proline → HCID 21906766, compound

Participants

Role	Name	HCID	Charge
Reactant	D-Proline	HCID 8988	—
Reactant	4-Hydroxypyrrolidine	HCID 98210	—
Reactant	2-Chloro-4-(4-(2-methoxy-phenylsulfanyl)-3-trifluoromethyl-phenyl)-pyridine	HCID 21906809	—
Product	HCID 21906766	HCID 21906766	—

Reaction Steps

The title compound was prepared according to the procedures of Example 38E, substituting compound 76 with compound 96 (0.039 g, 0.0985 mmol) and 3-hydroxypyrrolidine with (D)-proline. A yellow solid 100 was obtained (0.0366 g, 78%). 1H-NMR (CDCl3, 400 MHz) δ 2.14-2.38 (m, 3H), 2.48-2.55 (m, 1H), 3.58-3.66 (m, 1H), 3.80-3.89 (m, 1H), 3.83 (s, 3H), 4.96-5.05 (m, 1H), 6.82 (s, 1H), 6.96 (d, J=6.2 Hz, 1H), 7.01-7.07 (m, 3H), 7.46-7.52 (m, 3H), 7.84 (s, 1H), 8.04 (d, J=6.2 Hz, 1H). MS (APCI) m/z 475 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06787542B2
Source dataset	uspto-grants-2004_09
ORD ID	ord-4abcaef12e6e43a0ba6cc2317759e63f
Source note	uspto-grants-2004_09