HuagongsheHuagongshe Chemistry Print Report · For research reference only
D-Proline → 1-(4-(4-(2,3-Dihydro-benzo(1,4)dioxin-6-ylsulfanyl)-3-trifluoromethyl-phenyl)-pyridin-2-yl)-pyrrolidine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | D-Proline | HCID 8988 | — |
| Reactant | 4-Hydroxypyrrolidine | HCID 98210 | — |
| Reactant | 4-(4-(2,3-Dihydro-benzo(1,4)dioxin-6-ylsulfanyl)-3-trifluoromethyl-phenyl)-pyridine | HCID 86585867 | — |
| Product | 1-(4-(4-(2,3-Dihydro-benzo(1,4)dioxin-6-ylsulfanyl)-3-trifluoromethyl-phenyl)-pyridin-2-yl)-pyrrolidine-2-carboxylic acid | HCID 21906812 | — |
Reaction Steps
The title compound was prepared according to the procedures of Example 38E, substituting compound 76 with compound 118 (0.033 g, 0.0779 mmol) and 3-hydroxypyrrolidine with (D)-proline. A yellow solid 121 was obtained (0.035 g, 70%). MS (APCI) m/z 503 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06787542B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-73e13b3f63ed44a2aa3c3599e22afc81 |
| Source note | uspto-grants-2004_09 |