4-Hydroxypyrrolidine → (4'-(4-(2,3-Dihydro-benzo(1,4)dioxin-6-ylsulfanyl)-3-trifluoromethyl-phenyl)-3,4,5,6-tetrahydro-2H-(1,2')bipyridinyl-4-yl)-methanol

Participants

Reaction Steps

The title compound was prepared according to the procedures of Example 38E, substituting compound 76 with compound 118 (0.033 g, 0.0779 mmol) and 3-hydroxypyrrolidine with 4-piperidinemethanol. A yellow solid 122 was obtained (0.0284 g, 57%). 1H-NMR (CDCl3, 400 MHz) δ 1.41-1.51 (m, 2H), 1.86-1.95 (m, 1H), 1.97-2.04 (m, 2H), 3.23-3.31 (m, 2H), 3.57 (d, J=5.8 Hz, 2H), 4.28-4.34 (m, 4H), 4.36-4.41 (m, 2H), 6.92 (d, J=6.6 Hz, 1H), 6.93-6.97 (m, 2H), 7.05 (dd, J=1.8 Hz, 8.4 Hz, 1H),7.09 (d, J=1.8 Hz, 1H), 7.12 (d, J=8.4 Hz, 1H), 7.52 (d, J=8.4 Hz, 1H), 7.82 (s, 1H), 8.25 (d, J=6.6 Hz, 1H); MS (APCI) m/z 503 (M+H)+.

Provenance & Evidence