HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Piperidinecarboxamide → HCID 60108841, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Piperidinecarboxamide | HCID 3772 | — |
| Reactant | 4-Hydroxypyrrolidine | HCID 98210 | — |
| Reactant | 4-(4-(2,3-Dihydro-benzo(1,4)dioxin-6-ylsulfanyl)-3-trifluoromethyl-phenyl)-pyridine | HCID 86585867 | — |
| Product | HCID 60108841 | HCID 60108841 | — |
Reaction Steps
The title compound was prepared according to the procedures of Example 38E, substituting compound 76 with compound 118 (0.033 g, 0.0779 mmol) and 3-hydroxypyrrolidine with isonipecotamide. A yellow solid 126 was obtained (0.024 g, 47%). 1H-NMR (CDCl3, 400 MHz) δ 1.90-1.99 (m, 2H), 2.08-2.14 (m, 2H), 2.58-2.65 (m, 1H), 3.38-3.45 (m, 2H), 4.28-4.34 (m, 6H), 5.55 (br s, 1H), 5.97 (br s, 1H), 6.93-6.98 (m, 3H), 7.05 (dd, J=2.0 Hz, 8.2 Hz, 1H), 7.09 (d, J=1.8 Hz, 1H), 7.12 (d, J=8.4 Hz, 1H), 7.53 (d, J=8.4 Hz, 1H), 7.82 (s, 1H), 8.21 (d, J=6.6 Hz, 1H); MS (APCI) m/z 516 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06787542B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-7118196f5b0e4db09709c711884f6467 |
| Source note | uspto-grants-2004_09 |