4-Hydroxypyrrolidine → HCID 21906752, compound

Participants

Role	Name	HCID	Charge
Reactant	4-Hydroxypyrrolidine	HCID 98210	—
Reactant	Cis-4-Hydroxy-D-Proline	HCID 440014	—
Reactant	4-(4-(2,3-Dihydro-benzo(1,4)dioxin-6-ylsulfanyl)-3-trifluoromethyl-phenyl)-pyridine	HCID 86585867	—
Product	HCID 21906752	HCID 21906752	—

Reaction Steps

The title compound was prepared according to the procedures of Example 38E, substituting compound 76 with compound 118 (0.033 g, 0.0779 mmol) and 3-hydroxypyrrolidine with cis-4-hydroxy-D-proline. A yellow solid 130 was obtained (0.038 g, 74%). 1H-NMR (CDCl3, 400 MHz) δ 2.34-2.42 (m, 1H), 2.64-2.68 (m, 2H), 3.73-3.82 (m, 1H), 3.94-4.00 (m, 1H), 4.28-4.34 (m, 4H), 4.68-4.74 (m, 1H), 6.92-7.12 (m, 6H), 7.52 (br, 1H), 7.80 (s, 1H), 8.04 (br, 1H); MS (APCI) m/z 519 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06787542B2
Source dataset	uspto-grants-2004_09
ORD ID	ord-d5a9903e58b246638eba4e0c3efd3f91
Source note	uspto-grants-2004_09