4-Hydroxypyrrolidine → HCID 21906782, compound

Participants

Role	Name	HCID	Charge
Reactant	4-Hydroxypyrrolidine	HCID 98210	—
Reactant	Piperazine, 1-propyl-, hydrochloride (1:2)	HCID 415812	—
Reactant	4-(4-(2,3-Dihydro-benzo(1,4)dioxin-6-ylsulfanyl)-3-trifluoromethyl-phenyl)-pyridine	HCID 86585867	—
Product	HCID 21906782	HCID 21906782	—

Reaction Steps

The title compound was prepared according to the procedures of Example 38E, substituting compound 76 with compound 118 (0.033 g, 0.0779 mmol) and 3-hydroxypyrrolidine with 1-propylpiperazine. A yellow solid 135 was obtained (0.033 g, 64%). 1H-NMR (CDCl3, 400 MHz) δ 1.03 (t, J=7.3 Hz, 3H), 1.84-1.92 (m, 2H), 2.30-2.52 (br, 8H), 2.98-3.03 (m, 2H), 4.28-4.34 (m, 4H), 6.87 (s, 1H), 6.94 (d, J=1H), 7.01 (d, J=5.8 Hz, 1H), 7.04 (dd, J=2.2 Hz, 8.4 Hz, 1H), 7.09 (d, J=2.2 Hz, 1H), 7.13 (d, J=8.4 Hz, 1H), 7.51 (d, J=8.3 Hz, 1H), 7.82 (s, 1H), 8.26 (d, J=5.9 Hz, 1H), MS (APCI) m/z 516 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06787542B2
Source dataset	uspto-grants-2004_09
ORD ID	ord-ac2bd6989eea4cdf8742c847fe0abf80
Source note	uspto-grants-2004_09