HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-[(chlorosulfonyl)methyl]oxane-4-carboxylate → 4-[4-(4-Pyridin-3-yl-phenyl)piperazine-1-sulfonylmethyl]-tetrahydropyran-4-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-[(chlorosulfonyl)methyl]oxane-4-carboxylate | HCID 22228396 | — |
| Reactant | 1-(4-Pyridin-3-yl-phenyl)piperazine | HCID 22646684 | — |
| Reactant | 2-[4-(4-Bromo-phenyl)piperazine-1-sulfonylmethyl]3-methylbutyric acid tert-butyl ester | HCID 69895250 | — |
| Product | 4-[4-(4-Pyridin-3-yl-phenyl)piperazine-1-sulfonylmethyl]-tetrahydropyran-4-carboxylic acid methyl ester | HCID 69895116 | 55% |
Reaction Steps
Prepared according to the method for the preparation of 2-[4-(4-bromophenyl)piperazine-1-sulfonylmethyl]-3-methyl-butyric acid ter-butyl ester, from 1-(4-pyridin-3-yl-phenyl)piperazine (0.18 g) and 4-chlorosulfonylmethyl tetrahydropyran-4-carboxylic acid methyl ester (0.23 g), to yield the title compound as a white solid (0.19 g, 55%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06787536B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-165e072aa5eb4e269999b6b20e9b31ff |
| Source note | uspto-grants-2004_09 |