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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1005852Generated: October 27, 2026

1-(5-Bromopyrimidin-2-yl)piperazine → tert-Butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate

https://huagongshe.com/reaction/1005852

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(5-Bromopyrimidin-2-yl)piperazineHCID 2757175—
ReactantTert-butyl 4-(4-bromophenyl)piperazine-1-carboxylateHCID 11824027—
Producttert-Butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylateHCID 2191447693%

Reaction Steps

Prepared according to the method for the preparation of 4-(4-bromophenyl)-piperazine-1-carboxylic acid ter-butyl ester, from 5-bromo-2-piperazin-1-ylpyrimidine (5.00 g), to yield the title compound as a white solid (6.55 g, 93%)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06787536B2
Source datasetuspto-grants-2004_09
ORD IDord-2cf6e21bb76944739c9754a15b52d95f
Source noteuspto-grants-2004_09