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HRID1005871

反应详情

EQUATION

反应方程式

HRID 1005871 的结构方程式

REACTANTS

反应物

3
结构：c1cncc(B2OCCCO2)c1
HCID4198005

3-(1,3,2-dioxaborinan-2-yl)pyridine

C8H10BNO2

结构：CC(C)(C)OC(=O)N1CCN(c2ncc(Br)cn2)CC1
HCID21914476

tert-Butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate

C13H19BrN4O2

结构：CC(C)(C)OC(=O)N1CCN(c2ncc(-c3ccc(F)cc3)cn2)CC1
HCID69850026

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCN(c2ncc(-c3cccnc3)cn2)CC1
HCID69894987

未命名化合物

收率 99%

PROCEDURE

实验过程

Prepared according to the method for the preparation of 4-[5-(4-fluorophenyl)pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester, from 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (0.403 g) and pyridine-3-boronic acid 1,3-propanediol cyclic ester (0.211 g), to yield the title compound as an orange solid (0.399 g, 99%).

WORKUP

后处理

  1. customPrepared