5-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride → 2-Piperazin-1-yl-5-pyridin-3-ylpyrimidine, trihydrochloride

HRID 1005872Notes

Reaction equation

HRID 1005872 reaction equation
[ClH:1].Cl.FC1C=CC(C2C=NC(N3CCNCC3)=NC=2)=CC=1.C(OC([N:29]1[CH2:34][CH2:33][N:32]([C:35]2[N:40]=[CH:39][C:38]([C:41]3[CH:42]=[N:43][CH:44]=[CH:45][CH:46]=3)=[CH:37][N:36]=2)[CH2:31][CH2:30]1)=O)(C)(C)C>>[ClH:1].[ClH:1].[ClH:1].[N:32]1([C:35]2[N:40]=[CH:39][C:38]([C:41]3[CH:42]=[N:43][CH:44]=[CH:45][CH:46]=3)=[CH:37][N:36]=2)[CH2:31][CH2:30][NH:29][CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 226466725-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochlorideHCID 698949874-(5-Pyridin-3-ylpyrimidin-2-yl)piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 1317245812-Piperazin-1-yl-5-pyridin-3-ylpyrimidine, trihydrochlorideYield 96%

Procedure

Prepared according to the method for the preparation of 5-(4-fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride, from 4-(5-pyridin-3-ylpyrimidin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester (0.399 g), to furnish the title compound as an off-white solid (0.393 g, 96%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-32e465cda5c54a57bc4e5aae37cbba8a
Source dataset
uspto-grants-2004_09
Patent number
US06787536B2

Reaction notes

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