HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride → 1-{4-[5-(4-Fluorophenyl)pyrimidin-2-yl]piperazine-1-sulfonylmethyl}cyclohexanecarboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride | HCID 22646672 | — |
| Reactant | 4-(R)-benzyl-3(2-(R)-{4-[5-(4-fluorophenyl)pyrimidin-2-yl)piperazine-1-sulfonylmethyl}-3-methylbutyryl)oxazolidin-2-one | HCID 23519754 | — |
| Reactant | 1-Chlorosulfonylmethylcyclohexanecarboxylic acid methyl ester | HCID 58947956 | — |
| Product | 1-{4-[5-(4-Fluorophenyl)pyrimidin-2-yl]piperazine-1-sulfonylmethyl}cyclohexanecarboxylic acid methyl ester | HCID 69894795 | 48% |
Reaction Steps
Prepared according to the method for the preparation of 4-(R)-benzyl-3-(2-(R)-{4-[5-(4-fluorophenyl)pyrimidin-2-yl]piperazine-1-sulfonylmethyl}-3-methyl-butyryl)oxazolidin-2-one, from 5-(4-fluorophenyl)-2-piperazin-1-ylpyrimidine, dihydrochloride (0.599 g) and 1-chlorosulfonylmethylcyclohexanecarboxylic acid methyl ester (0.575 g), to yield the title compound as a white solid (0.417 g, 48%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06787536B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-b54ffc7e9aef4b70b964fce8c597a5d1 |
| Source note | uspto-grants-2004_09 |